Role of vinca alkaloids and their derivatives in cancer therapy

Vinca alkaloids and its derivatives like Vincristine, Vinblastine etc. isolated from Catharanthus roseus plants are widely used in the treatment of various types cancers. Mode action (vinblastine, vincristine, vinorelbine) is microtubule-stabilizing agents (MTAs) i.e., arrest cell cycle via disrupting microtubule dynamics. Vincristine major side effect neurotoxicity. Hoverer, induce neuropathy mice or rat, as animal model to study drugs by authors also reported review literature. were combination regimens with cyclophosphamide, doxorubicin, procarbazine, Methotrexate dacarbazine cancer. In this review, we discussed structure modifications position chemically synthesized vincristine vinblastine required for potential anticancer activities. Anticancer mechanism some patents on vinca article. The a class an antimitotic compounds, found essential role therapies.